$re = '/^[^_]*_|_\d+_\d+\.[^.]*$/m';
$str = 'Doc20191001119049_fotocontargasx_3962122_943000.jpg
Doc201810011052053_fotoAssicurazioneCartaceo_3962128_943000.jpg
Doc201910011214020_fotoesterna_ant_396024_947112.jpg
Doc201710071149010_foto_TargaMid_4007396_95010.jpg';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php