use strict;
my $str = '፻this test works፻
፻this test does not work፻
this is a line that stays unchanged
this is a line that stays unchanged፻
፻this is a line that stays unchanged';
my $regex = qr/(?<=^፻.+)\b(?=\w.*፻$)/mp;
my $subst = '፻';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html