$re = '/^(?>(?!\2\b|\3\b)(1\d{1}|2[0-2]{1}|\d{1}+)[,.; ]+)(?>(?!\1\b|\3\b)(1\d{1}|2[0-2]{1}|\d{1}+)[,.; ]+)(?>(?!\1\b|\2\b)(1\d{1}|2[0-2]{1}|\d{1}+))$/m';
$str = '1,2,12
22,3, 21
1,,,,22,,,,19
9. 12,.. 8
1.1. 2
2. 1. 2
3,3,12';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php