$re = '/^[^0-9\n]*(?:((?|[12](?=(?>.*\n)*([^#]+))|3(?=(?>.*\n)*[^#]*#([^#]+))|[45](?=(?>.*\n)*(?:[^#]*#){2}([^#]+)))\d+).*|.*\z)/m';
$str = 'Blah 12345 Blah
Blah 22345 Blah
Blah 32345 Blah
Blah 42345 Blah
Blah 52345 Blah
AAA#BBB#XYZ';
$subst = "$2$1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php