$re = '/<!--(.|\s)*?-->/m';
$str = 'blablabla
<teste>teste</teste>
etc
<!-- Assinatura principal -->
<x>mais conteúdo</x>
<!-- [if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:AllowPNG /> </o:OfficeDocumentSettings> </xml><![endif]-->
blablabla
<!---->
<!--
-->
<p>lorem ipsum</p>
<!-- <!-- fad ->----->';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php