$re = '/(?<!\/\/)\s*define\s*\(\s*([\'"])WP_CACHE\1\s*,\s*(?:\-?[1-9][0-9\.]*|TRUE|([\'"])(?:[^0\'"]|[^\'"]{2,})\2)\s*\)\s*/i';
$str = '//define(\'WP_CACHE\', true); //Added by WP-Cache Manager';
$subst = "";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php