import re
regex = re.compile(r"(date_from_to=)(?:.+?)(&)")
test_str = "posutochnaja-arenda-nedvizhimost-v-yalte/zhk-morskoy-spusk-v-yalte-id20879?date_from_to=01.12.2021-03.12.2021&clear_cache=Y&_r=3298#rooms-header-block"
subst = "$1****"
result = regex.sub(subst, test_str)
if result:
print(result)
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Python, please visit: https://docs.python.org/3/library/re.html