const regex = new RegExp('[2][0-9][0-9][0-9]\\/[0-9][[0-9]\\/', 'i')
const str = `161 1 2015/12/17 14:52:08:44648 13668 38528 1 *** 15 5 CDF_ENTRY [Id=1] hook_MFCreateSourceResolver: Entering.
162 1 2015/12/17 14:52:08:44664 13668 38528 1 *** 15 5 CDF_ENTRY [Id=2] SourceResolverWrapper::FinalConstruct: Entering.
163 1 2015/12/17 14:52:08:44664 13668 38528 1 *** 20 5 CDF_ENTRY [Id=2] SourceResolverWrapper::FinalConstruct: Leaving. (hr=0x0)
164 1 2015/12/17 14:52:08:44665 13668 38528 1 *** 20 5 CDF_ENTRY [Id=1] hook_MFCreateSourceResolver: Leaving. (hr=0x0)
165 1 2015/12/17 14:52:08:44666 13668 38528 1 *** 15 5 CDF_ENTRY [Id=2] SourceResolverWrapper::BeginCreateObjectFromURL: Entering. `;
const subst = `2016/01/`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions