$re = '/(Sample2).*(\d{2}-\d{2}-\d{4}).*(?<=[a-z]_)(\d+)(?=_\d+).*(?<=_)(\d+)$/i';
$str = 'Sample1_Sample2_1_05-11-2015_0_Sample3-AB_C_D_045_4_Sample4_123456';
preg_match($re, $str, $matches, PREG_OFFSET_CAPTURE, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php