const regex = /(?<=,|^)(?:[0.+-]+(?=0(?:,|\.\B|$))|0+(?=[1-9]))|\.0+\b|\b0+(?=\d*\.\b)|\.\B|(?<=[1-9])0+(?=,|$)/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(?<=,|^)(?:[0.+-]+(?=0(?:,|\\.\\B|$))|0+(?=[1-9]))|\\.0+\\b|\\b0+(?=\\d*\\.\\b)|\\.\\B|(?<=[1-9])0+(?=,|$)', 'g')
const str = `2.0,3.00,-4.0,0.00,-0.00,0.03,2.01,0.001,-0.03,101,-00.,0.,01,1.10,000.,.000,0.000,-004.04`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions