use strict;
my $str = '2.0,3.00,-4.0,0.00,-0.00,0.03,2.01,0.001,-0.03,101,-00.,0.,01,1.10,000.,.000,0.000,-004.04';
my $regex = qr/(?<=,|^)(?:[0.+-]+(?=0(?:,|\.\B|$))|0+(?=[1-9]))|\.0+\b|\b0+(?=\d*\.\b)|\.\B|(?<=[1-9])0+(?=,|$)/p;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html