re = /^(?![0-9a-zA-Z]+:[0-9a-zA-Z]+$).*$\R*/m
str = 'local06:local16
TEXT local76:local16
local06:local17
local06:local19
More TEXT local76:local678'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html