use strict;
my $str = 'url.com/folder1/xxx/index.html
url.com/folder2/
url.com/folder3/xxx/yyyy/index.html
url.com/folder4/zzz/aaa/bbb/index.html';
my $regex = qr/^.*?\/.*?\/\K.*$/mp;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html