const regex = /OPTIONS=\"(.*?)(-u\s[A-Za-z0-9\-_]+:[A-Za-z0-9\-_]+)?(.*?)\"/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('OPTIONS=\\"(.*?)(-u\\s[A-Za-z0-9\\-_]+:[A-Za-z0-9\\-_]+)?(.*?)\\"', 'g')
const str = `OPTIONS="-x -u wrong:wrong -c blah"
OPTIONS="-u wrong:wrong -x -c blah"
OPTIONS="-x -c blah -u wrong:wrong"
OPTIONS="-x -c blah"
`;
const subst = `OPTIONS="\1 \3 -u ntpd:ntpd"`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions