$re = '/^(?!.*\/changelogs(?:\/|$)).*\/(\d+)/mi';
$str = 'http://www.opera.com/docs/changelogs/unified/1215/
http://www.whatever.com/docs/changelogs/anythingelse/anything/1215/
http://www.blabblah/security/advisory/1047
http://booger/security/advisory/1048/
ftp://msn.global.whatever/somethingelse/1245
whatever/it/doesnt/matter/could/be/anything/i/still/want/this/number/1049/';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php