$re = '/^(?:GET|HEAD):.*?application\/(?:activity|ld)\+json/m';
$str = '======================================================
Basic testing with "just" the expexted pattern
======================================================
GET:application/activity+json
GET:application/activity+xml
HEAD:application/activity+json
POST:application/activity+json
GET:application/ld+json
GET:application/ld+xml
HEAD:application/ld+json
POST:application/ld+json
======================================================
Testing with additional suffix in the header
======================================================
GET:application/activity+json,something,else
GET:application/activity+xml,something,else
HEAD:application/activity+json,something,else
POST:application/activity+json,something,else
GET:application/ld+json,something,else
GET:application/ld+xml,something,else
HEAD:application/ld+json,something,else
POST:application/ld+json,something,else
======================================================
Testing with additional prefix *and* suffix in the header
======================================================
GET:something before, application/activity+json, something, after
GET:something before, application/activity+xml, something, after
HEAD:something before, application/activity+json, something, after
POST:something before, application/activity+json, something, after
GET:something before, application/ld+json, something, after
GET:something before, application/ld+xml, something, after
HEAD:something before, application/ld+json, something, after
POST:something before, application/ld+json, something, after';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php