$re = '/\x3ci\x3e(.{1,3})\x3c\/i\x3e/';
$str = 'La vida <i>es</i> bella.';
$subst = "$1";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php