use strict;
my $str = 't1E2S3T
t1E2S33';
my $regex = qr/^(?=(?:[^a-zA-Z\n]*[a-zA-Z]){4}[^a-zA-Z\n]*$)(?=(?:[^\d\n]*\d){3}[^\d\n]*$)/mp;
my $subst = '$1';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html