$re = '/^(?=(?:[^a-zA-Z\n]*[a-zA-Z]){4}[^a-zA-Z\n]*$)(?=(?:[^\d\n]*\d){3}[^\d\n]*$)/m';
$str = 't1E2S3T
t1E2S33';
$subst = "$1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php