const regex = new RegExp('\\[\\?\\](?:(?!\\[/?\\?\\]).)*%empty%(?:(?!\\[\\?\\]).)*\\[/\\?]', 'gms')
const str = `[?]<h1>%empty%</h1>
<p>text</p>
[/?]
text
[?]<h1>%empty%</h1>
<p>text</p>
[/?]
text
[?]<h1>%!empty%</h1>
<p>text</p>
[/?]
text
[?][][/<h1>%empty%</h1>][][[[]]]
<p>text</p>
[/?]
[?]<h1>%empty%</h1>
<p>text</p>[?]
[/?]
text[?]<h1>%!empty%</h1>
<p>text</p>
[/?] `;
const subst = `REPLACED`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions