const regex = /\n*\d+:\d+:\d+\.\d+,\d+:\d+:\d+\.\d+\n(.*)/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('\\n*\\d+:\\d+:\\d+\\.\\d+,\\d+:\\d+:\\d+\\.\\d+\\n(.*)', 'g')
const str = `0:04:10.700,0:04:11.360
but
0:04:11.360,0:04:15.680
but it was plenty big you know the silo itself would have easily been
0:04:16.180,0:04:18.420
as wide as this room is
0:04:18.420,0:04:23.200
and perhaps larger and many, many, story's tall, you know because it was nested underground`;
const subst = `$1 `;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions