const regex = /(?::|^)((?:0+:){2,}0+)(?=:|$)|(?::|^)(0+)([0-9a-f]+)(?=:|$)|\b0+([0-9a-f]{1,4})\b/gi;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(?::|^)((?:0+:){2,}0+)(?=:|$)|(?::|^)(0+)([0-9a-f]+)(?=:|$)|\\b0+([0-9a-f]{1,4})\\b', 'gi')
const str = `2001:0db8:abcd:0012:0000:0000:0000:0001
2001:0db8:abcd:0012:0000:0000:0000:00a2
2001:0db8:abcd:0012:0000:0000:0000:00ff
a:b:0:c:d:e:f:g
2001:0db8:abcd:0012:0000:0000:0000:0001
:00ff:0000:
0012:0000:0000:0000:0001`;
const subst = `${1:+::}${3}${4}`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions