$re = '/^(?!(\d)(?:[:-]?\1)*$)([0-9A-Fa-f]{2}[:-]){5}([0-9A-Fa-f]{2})$/m';
$str = '00:00:00:00:00:01
00:00:00:00:00:00
00:00:00:00:00:00
11:11:11:11:11:11
99-99-99-99-99-99
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php