use strict;
my $str = 'This is a #text, which is #full of #hashtags.
Well, this is not #easy to
#extract #them.
I think I #start to lose: #hope.';
my $regex = qr/([\s\.\,]|^)[^#]\w+([\s\.\,]*?|$)/mp;
my $subst = '$2';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html