const regex = new RegExp('(?:\\G(?!^)|^((?:/[^/\\n]*){3}/))([^\\d\\n]*)\\d', 'gm')
const str = `/path/to/something/1234/end
/path/to/something/12/1234/end
/FWS/teis-facade-rest_v712/flk/tariffs/114776/14/options
/mem-utms-facade/v1.2/rest/URA/ST00006486/note
/FWS/spg-facade/eis/2650114465322000006/contract
/FWS/fanotical-soyarty-service/flk/lk_2456882/bonusFlk`;
const subst = `$1$2#`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions