$re = '/(?i)\b(?=https?:\/\/|)(?<!clips\.)twitch\.tv\/(?!minokawa95)\b/m';
$str = 'twitch.tv/minokawa95
TWITCH.TV/MINOKAWA95
http://twitch.tv/minokawa95
HTTP://TWITCH.TV/MINOKAWA95
https://twitch.tv/minokawa95
HTTPS://TWITCH.TV/minokawa95
twitch.tv/notminokawa95
TWITCH.TV/NOTMINOKAWA95
http://twitch.tv/notminokawa95
HTTP://TWITCH.TV/NOTMINOKAWA95
https://twitch.tv/notminokawa95
HTTPS://TWITCH.TV/NOTMINOKAWA95
clips.twitch.tv/SampleShitSeven
CLIPS.TWITCH.TV/SAMPLESHITSEVEN
http://clips.twitch.tv/SampleShitSeven
HTTP://CLIPS.TWITCH.TV/SAMPLESHITSEVEN
https://clips.twitch.tv/SampleShitSeven
HTTPS://CLIPS.TWITCH.TV/SAMPLESHITSEVEN
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php