const regex = /\s*\b\d+\b\s*/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('\\s*\\b\\d+\\b\\s*', 'gm')
const str = `0 I64 EB MM 93
1519 KINGSCROSS RD
28 VA288 298
JOHN RANDOLPH RD
4700 WALMSLEY BL
BOWLING GREEN RD / BOB WHITE RD
BRUCE CT /FLORIDA AV
BUCK RD AND WHITEHALL RD
DOWNTOWN EWRESSWY EB 2ND ST
HYHLAND VISTA / GEORGE WASHINGTON BL
HYHLAND VISTA / GEORGE WASHINGTON BL
HYHLAND VISTA DR / GEORGE WASHINGTON BL
I95 25 43
LAUARL RIDGE MILL RD /CLARENCE RD
LAUARL RIDGE MILL RD /CLARENCE RD
NOVAH HOWARD ST /SEMINARY RD
OLD COUVAHOUSE RD R COUVAHOUSE RD
OLD COUVAHOUSE RD R COUVAHOUSE RD
WOODLAND AND ROANOKE
1501 SAMS CR1
15281 WHITEHEAD RD
1532 MARLBORO ST
16907 BRANDERS BRIDGE RD
1750 WILLIAM ST`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions