use strict;
my $str = 'file Science/Chemistry/Quantum 444 1
file Marvel/CaptainAmerica 342 0
file DC/JusticeLeague/Superman 300 0
file Math 333 0
file Biology 224 1';
my $regex = qr/(file\s)([A-Za-z]+(?=\/|\s))(.*)(\d{3})/mp;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html