$re = '/weeks?\h*\K0+(?=[1-9]\d*[a-zA-Z])/m';
$str = 'week 01st
weeks 02nd
year2022week01st
week 4th';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php