re = /weeks?\h*\K0+(?=[1-9]\d*[a-zA-Z])/m
str = 'week 01st
weeks 02nd
year2022week01st
week 4th'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html