$re = '/[:*\n]/';
$str = 'Languages: JAVA (2 years), Python (6 months), C (1 year), C++
Web Technologies: HTML, CSS3, PHP, JavaScript, JQuery, AJAX, Bootstrap, WordPress, JSP, Servlets, HTTP, XML, JSON
Databases: MySQL, PostgreSQL Amazon RDS, Dynamo DB, Google Cloud Datastore, SQL expert, NoSQL
Frameworks: Flask, SQL-Alchemy, Hive, JPA, Hibernate, Weka, NumPy, Pandas
Tools/Technology: Eclipse, PyCharm, Docker, AWS, Terminal, Unix Scripting, Tomcat, Maven, GIT, SVN, Arduino, PIC
';
$subst = ",";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php