$re = '/\b[uU](?=\b|(?![^\W\d_]))\.?\s*/m';
$str = 'Holics u 5/a",
"Holics U 5/a",
"Holics u5/a",
"Huolics u 5/a",
"Holics u. 5/a",
"Holuics u5",
"Holics and other stuff u more stuff after 5",
"Houlics utca 5';
$subst = "utca ";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php