$re = '/^((?!(\?)|(\[))(.+(\n|$)))+/m';
$str = 'this is paragraph line1 line 1
and line 2
?[question_2]{"category":[]}[who are you]=[] {1,2}
[] OPTION 1
[] OPTION 2
[] OPTION 3
this is paragraph line3
with a line break
?[question_3]{"category":[]}[picode]=_ [PLACEHOLDER_TEXT]
?[question_1]{"category":[]}[sex]=() {1}
() male
() femele
this is paragraph line3
in the end of file';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php