$re = '/(?<!\{|function )(\{\{(?!#|\{|\d|[A-Z]+|[<>])|invoke:|[Cc]ategory:|[Mm]odule:|[Pp]ortal:)(?!Wt/ckb|gsub\()/';
$str = '{{<includeonly>safesubst:</includeonly>#invoke:ping user|ping}}<noinclude>{{documentation}}</noinclude>';
$subst = "$1Wt/ckb/";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php