import Foundation
let pattern = ##"(ABC[#:*$]+(?:\w+[#:*$]+){2}|DEF[#:*$]+(?:\w+[#:*$]+){3})([^#:*$]+)(.+)"##
let regex = try! NSRegularExpression(pattern: pattern)
let testString = #####"""
ABC#12#3#LINE1####1234678985$
DEF#XY#Z:1234:1234561230$
ABC#12#3#LINE TWO####1234678985$
DEF#XY#Z:1234:4564561230$
ABC#12#3#3RD LINE####1234678985$
DEF#XY#Z*1234:7894561230$
"""#####
let stringRange = NSRange(location: 0, length: testString.utf16.count)
let substitutionString = #"\1 + replacement + \3"#
let result = regex.stringByReplacingMatches(in: testString, range: stringRange, withTemplate: substitutionString)
print(result)
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Swift 5.2, please visit: https://developer.apple.com/documentation/foundation/nsregularexpression