use strict;
my $str = '<p alt="100">100</p>
<img src="100.jpg">100</ing>
<span alt="tel:100">100</span>
';
my $regex = qr/"[^"]*"(*SKIP)(*F)|\b100\b/mp;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html