# If you'd like to omit non-matching lines from the result; add ';d' to the end of the expression.
sed -E 's/(?mi)^\d+.+\d{4}-\d{2}-\d{2},\h+\d{1,2}:\d{1,2}:\d{1,2}\h+(.+)/\1/gu;t' <<< "10 Highlight 2020-11-20, 21:48:47 Lorem ipsum Case 1...
90 Highlight 2020-11-20, 21:35:17 Lorem ipsum Case 2...
2 Highlight John Smith 2020-11-20, 17:19:26 Lorem ipsum Case 3..."
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for SED, please visit: https://www.gnu.org/software/sed/manual/html_node/The-_0022s_0022-Command.html