$re = '/(?!\([^\s*\,])\s*,\s*(?![^"\']*(\'|")\))/';
$str = 'sdfsf,sdfsdf,asdsd(),sdfsdf(\'3\',33, "22"),dfgdfgdg,sdfsdf("hg,gh"),jhkjh(\',k,k\'),jhkjh(\'sd,\'),jhkjh(\'sd\'),asdad(\',\'),asdasd(",sss"),kjkj,hghjg(",jhgjh,h"),sdfsf:jhjh(""),sdfsf:jhjh("asd()asd,()"),hghjg(",("),hghjg(\',(WE2\'),ASDASD,sdfsf:jhjh("asd(), asd)"),';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php