const regex = /^[\d\/ :]+:[^:]+:(.*)$|(.*)$/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('^[\\d\\\/ :]+:[^:]+:(.*)$|(.*)$', 'gm')
const str = `11/04/2015 11:45:01: James: Cheers guys, enjoy the weekend!
11/04/2015 12:08:55: Sarah: Sounds good James
11/04/2015 12:09:24: Sarah: What are the details of the trip?
11/04/2015 12:19:06: Leah: Driving up on Friday.
Saturday we'll hit the beach.
Sunday paaaaarty!
11/04/2015 12:29:54: James: Nice.`;
const subst = `$1$2`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions