$re = '/(?<!\d\d)([.:])(?!\d+)/m';
$str = '1992.01.04 is my birthday.
The time is 11:48, reported by: Tom.';
$subst = " \1 ";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php