$re = '/^(?:[^;]*;){4}([^;]*;[^;]*);/';
$str = '42441;27;nombre;apellidos;direccion; 8-2º; SEVILLA;SEVILLA;12345;texto;123456789;;test@gmail.com;123456;;1900-08-20;1904-06-30 00:00:00;0000-00-00 00:00:00;2;1;0000-00-00;0000;1111;1111;11;0123456789;;18;0;0;2;15;ES11';
preg_match($re, $str, $matches, PREG_OFFSET_CAPTURE, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php