$re = '/(.*?)a\)/s';
$str = 'pergunta pergunta pergunta pergunta pergunta pergunta pergunta pergunta pergunta pergunta pergunta pergunta pergunta pergunta pergunta
a) resposta a
b) resposta b
c) resposta c
d) resposta d
e) resposta e';
$subst = " ";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php