$re = '/(?<=^FS-[a-zA-Z0-9]*)[a-z]|[\p{Zs}\ta-z](?=[a-zA-Z0-9\p{Zs}\t]*$)/m';
$str = '(S)FSK-69/23/GFK/ 1 2
(S)FSK-69/23/GFK/12
FS-4444g/23g/F/1g1
FS-4444/23g/F/11';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php