use strict;
my $str = 'I\'m one of the persons\' stackoverflow don\'t th\'em said, \'hey what\' I\'ll handle it.';
my $regex = qr/(?<!s)'(?!(?:t|ll|e?m)\b)/p;
my $subst = '"';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html