const regex = /,(?=[^(]*\))/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp(',(?=[^(]*\\))', 'g')
const str = `Lorem ipsum dolor sit amet, consetetur sadipscing (elitr, sed diam nonumy eirmod tempor invidunt, ut labore, et dolore magna aliquyam erat), (sed diam) voluptua. (At, vero) eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.`;
const subst = `+`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions