$re = '/name_of_file\K\d*(?=\d{6}\.A\d{3})/m';
$str = 'name_of_file210618.A001.6476871457
name_of_file0000000546210618.A001.6476871457';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php