re = /.*(BARCODE).*\n.*\n.*\n.*/m
str = 'this is a line
this is a line
this is a line BARCODE
this is a line1
this is a line2
this is a line3
this is a linethis is a line
this is a line'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html