$re = '/Debug.*?endmsg(*SKIP)(*F)|restart-required/';
$str = 'Debug: testing message with no restart-required.endmsg.Warn:garbagestuff.Debug: another message.endmsg.Warn:moregarbage.Debug: this testing message has restart-required.endmsg.Error:server 404 not found.Critical restart-required. Debug: blah blah restart-required.endmsg.';
$subst = "";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php