use strict;
my $str = '#,0000:10100010~;1000_0101;1001_0110;1010_0111;1011_1000;1100_1001;1101_1010;1110_1011;1111_1100,~0_00001_00012_00103_00114_01005_01016_01107_01118_10009_1001,';
my $regex = qr/#.*:|~.*/p;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html