$re = '/#.*:|~.*/';
$str = '#,0000:10100010~;1000_0101;1001_0110;1010_0111;1011_1000;1100_1001;1101_1010;1110_1011;1111_1100,~0_00001_00012_00103_00114_01005_01016_01107_01118_10009_1001,';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php